> For the complete documentation index, see [llms.txt](https://www.brexatlas.org/llms.txt). Markdown versions of documentation pages are available by appending `.md` to page URLs; this page is available as [Markdown](https://www.brexatlas.org/author_index/cell_line_index.md).

# CELL\_LINE\_INDEX

## Glioblastoma

| Cell Line | Cancer Type  | BRE Entries               | Subjects                                                            |
| --------- | ------------ | ------------------------- | ------------------------------------------------------------------- |
| F-98      | Glioblastoma | BRE-001, BRE-002          | Foundational TTFields, Frequency Optimization                       |
| U-87      | Glioblastoma | BRE-001, BRE-002, BRE-036 | Foundational TTFields, Frequency Optimization, Clinical Translation |
| U-118     | Glioblastoma | BRE-001, BRE-002, BRE-036 | Foundational TTFields, Frequency Optimization, Clinical Translation |
| S24       | Glioblastoma | BRE-042                   | Tumor Network Biology                                               |
| BG5       | Glioblastoma | BRE-042                   | Tumor Network Biology                                               |
| T269      | Glioblastoma | BRE-042                   | Tumor Network Biology                                               |

## Breast Cancer

| Cell Line                          | Cancer Type                    | BRE Entries                                 | Subjects                                                                                              |
| ---------------------------------- | ------------------------------ | ------------------------------------------- | ----------------------------------------------------------------------------------------------------- |
| MCF7                               | Breast Cancer                  | BRE-022, BRE-023, BRE-031, BRE-032          | Nanoparticle Amplification, Membrane Potential, Bioelectric Dysregulation, Calcium Vulnerability      |
| MDA-MB-231                         | Breast Cancer                  | BRE-002, BRE-023, BRE-030, BRE-031, BRE-032 | Frequency Response, Membrane Potential, Brain Metastasis, Bioelectric Dysregulation, Calcium Channels |
| T47D                               | Breast Cancer                  | BRE-024, BRE-030                            | ROS Signaling, RF Frequency Response                                                                  |
| BT-474                             | Breast Cancer                  | BRE-030                                     | Brain Metastasis RF Response                                                                          |
| SKBrM3                             | Breast Cancer Brain Metastasis | BRE-030                                     | Brain Metastasis RF Response                                                                          |
| 231-BrM                            | Breast Cancer Brain Metastasis | BRE-030                                     | Brain Metastasis RF Response                                                                          |
| Murine 16/C Mammary Adenocarcinoma | Breast Cancer                  | BRE-025                                     | Anti-Angiogenesis and Tumor Vascular Suppression                                                      |

## Liver Cancer (Hepatocellular Carcinoma)

| Cell Line | Cancer Type                                 | BRE Entries      | Subjects                                   |
| --------- | ------------------------------------------- | ---------------- | ------------------------------------------ |
| HepG2     | Hepatocellular Carcinoma (Liver Cancer)     | BRE-033, BRE-034 | TTFields + Sorafenib, ER Stress, Autophagy |
| Hep3B     | Hepatocellular Carcinoma (Liver Cancer)     | BRE-033          | TTFields + Sorafenib                       |
| Huh-7D12  | Hepatocellular Carcinoma (Liver Cancer)     | BRE-034          | ER Stress and Autophagy                    |
| N1S1      | Hepatocellular Carcinoma (Orthotopic Model) | BRE-034          | In-Vivo TTFields Validation                |

## Lung Cancer

| Cell Line | Cancer Type                        | BRE Entries      | Subjects                                              |
| --------- | ---------------------------------- | ---------------- | ----------------------------------------------------- |
| A549      | Non-Small Cell Lung Cancer (NSCLC) | BRE-018, BRE-039 | Radiation Sensitization, Triple Therapy Amplification |
| H460      | Non-Small Cell Lung Cancer (NSCLC) | BRE-039          | Triple Therapy Amplification                          |

## Pancreatic Cancer

| Cell Line                | Cancer Type       | BRE Entries | Subjects                                     |
| ------------------------ | ----------------- | ----------- | -------------------------------------------- |
| Pancreatic Cancer Models | Pancreatic Cancer | BRE-004     | Mitotic Disruption and Reduced Clonogenicity |

## Melanoma

| Cell Line | Cancer Type | BRE Entries | Subjects               |
| --------- | ----------- | ----------- | ---------------------- |
| B16F1     | Melanoma    | BRE-002     | Frequency Optimization |
| B16-BL6   | Melanoma    | BRE-032     | Calcium Vulnerability  |

## Cervical Cancer

| Cell Line | Cancer Type     | BRE Entries | Subjects                             |
| --------- | --------------- | ----------- | ------------------------------------ |
| HeLa      | Cervical Cancer | BRE-032     | T-Type Calcium Channel Vulnerability |

## Liposarcoma

| Cell Line | Cancer Type | BRE Entries | Subjects                       |
| --------- | ----------- | ----------- | ------------------------------ |
| SW872     | Liposarcoma | BRE-040     | Sarcoma TTFields Sensitization |
| 94T778    | Liposarcoma | BRE-040     | Sarcoma TTFields Sensitization |

## Brain Tumor Models

| Cell Line                 | Cancer Type                      | BRE Entries | Subjects                             |
| ------------------------- | -------------------------------- | ----------- | ------------------------------------ |
| Primary GBM Cells         | Glioblastoma                     | BRE-035     | Mitochondrial Respiration Disruption |
| DIPG Models               | Diffuse Intrinsic Pontine Glioma | BRE-035     | Mitochondrial Respiration Disruption |
| Meningioma Models         | Meningioma                       | BRE-035     | Mitochondrial Respiration Disruption |
| Patient-Derived Tumoroids | Glioblastoma                     | BRE-042     | Tumor Network Biology                |
| Brain Tumor Organoids     | Glioblastoma                     | BRE-042     | Tumor Network Biology                |

## Multi-Tissue and Engineering Models

| Cell Line        | Cancer Type                               | BRE Entries | Subjects                                       |
| ---------------- | ----------------------------------------- | ----------- | ---------------------------------------------- |
| U2OS             | Osteosarcoma / Engineering Model          | BRE-041     | Ferroelectric Nanoparticle Field Amplification |
| HEK293           | Human Embryonic Kidney (Research Model)   | BRE-032     | Calcium Vulnerability                          |
| HSG              | Human Salivary Gland (Research Model)     | BRE-032     | Calcium Vulnerability                          |
| Xenopus Models   | Developmental / Bioelectric Systems Model | BRE-031     | Bioelectric Dysregulation in Cancer            |
| Zebrafish Models | Developmental / Bioelectric Systems Model | BRE-031     | Bioelectric Dysregulation in Cancer            |

## Clinical and Population-Level Systems

| Study Type                       | BRE Entries      | Subjects                                                  |
| -------------------------------- | ---------------- | --------------------------------------------------------- |
| Clinical Glioblastoma Patients   | BRE-038          | TTFields Safety and Tolerability                          |
| Mesothelioma Clinical Systems    | BRE-037          | Clinical Thoracic TTFields                                |
| Breast Cancer Population Studies | BRE-028, BRE-029 | Environmental EMF Risk, Melatonin and Circadian Signaling |
| Radiation Signaling Models       | BRE-044          | Bioelectric Bystander Signaling                           |


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